gt.geometric topology - Ramified cover of 4-sphere

The answer is yes, at least if we interpret your phrase "ramification of order 2" to mean "simple branched covering". See Piergallini, R., Four-manifolds as $4$-fold branched covers of $S^4$. Topology 34 (1995), no. 3, 497--508. Any closed, orientable PL 4-manifold can be expressed as a 4-fold simple branched covering of S⁴ branched along an immersed surface with only transverse double points. It is apparently still an open question whether the branch set can be chosen to be nonsingular. A simple branched covering of degree d is a branched covering in which each branch point is covered by d-1 points, only one of which is singular, of local degree 2.